Journal: Microelectronic Engineering

Article Title: Diagnostic tools for tackling febrile illness and enhancing patient management

doi: 10.1016/j.mee.2018.10.001

Figure Lengend Snippet: Classification of fever-causing pathogens in Africa (parasitic, bacterial, viral, fungal systemic infections). “NA”: Not Applicable; “?”: unknown; “NAATs”: Nucleic Acid Amplification Technologies; “LFT”: Lateral Flow Test.

Article Snippet: Several technologies have been developed based on colorimetric (e.g. colloidal gold or colored latex) or fluorescence detection, by commercial suppliers: ESEQuant™ LFT strip reader by Qiagen Lake Constance (Germany); an imaging system by Axxin Inc. (Australia); the handheld image capture LFT reader by Detekt Biomedical, LCC (USA); the cPOC™ reader from LRE Medical (Germany); the handheld DCN Fluorescent Test Visualizer (USA) [ ].

Techniques: Amplification, Infection

Journal: Microelectronic Engineering

Article Title: Diagnostic tools for tackling febrile illness and enhancing patient management

doi: 10.1016/j.mee.2018.10.001

Figure Lengend Snippet: Overview of the described point-of-care and near-patient NAATs from the customer perspective.

Article Snippet: Several technologies have been developed based on colorimetric (e.g. colloidal gold or colored latex) or fluorescence detection, by commercial suppliers: ESEQuant™ LFT strip reader by Qiagen Lake Constance (Germany); an imaging system by Axxin Inc. (Australia); the handheld image capture LFT reader by Detekt Biomedical, LCC (USA); the cPOC™ reader from LRE Medical (Germany); the handheld DCN Fluorescent Test Visualizer (USA) [ ].

Techniques: Luminex

Journal: Microelectronic Engineering

Article Title: Diagnostic tools for tackling febrile illness and enhancing patient management

doi: 10.1016/j.mee.2018.10.001

Figure Lengend Snippet: The Q-POC™ system (handheld, smartphone-sized). Image source: used from .

Article Snippet: Several technologies have been developed based on colorimetric (e.g. colloidal gold or colored latex) or fluorescence detection, by commercial suppliers: ESEQuant™ LFT strip reader by Qiagen Lake Constance (Germany); an imaging system by Axxin Inc. (Australia); the handheld image capture LFT reader by Detekt Biomedical, LCC (USA); the cPOC™ reader from LRE Medical (Germany); the handheld DCN Fluorescent Test Visualizer (USA) [ ].

Techniques:

Journal: Microelectronic Engineering

Article Title: Diagnostic tools for tackling febrile illness and enhancing patient management

doi: 10.1016/j.mee.2018.10.001

Figure Lengend Snippet: Schematic of the Q-POC™ microfluidic chip. (a) Sample inlet. (b) Lysis chamber for releasing the DNA from the cells (or, with the use of appropriate membrane, for withholding the cells if circulating DNA is required for analysis). (c) Nucleic acid purification, by keeping all lysate components on a membrane. (d) Nucleic acid amplification area (continuous flow PCR). (e) Post-amplification and pre-analysis processing (its necessity depends on the application). (f) Connecting fluidic channel. (g) Metal contacts, providing the interface with the handheld device. (h) Sensitive SiNW arrays. (i) Meander-shaped microfluidic channel filled with reagents that are released at will to area (g)/(h). In particular, reagents may include various nucleotide mixtures and wash solutions, all separated by air bubble(s), in order to flow sequentially and in a well-controlled way. When nucleotides flow sequentially over a nanowire-immobilized single stranded oligonucleotide, then according to the hybridization sequence, the local charge changes, causing a resistance change in the SiNW. Image source: used from .

Article Snippet: Several technologies have been developed based on colorimetric (e.g. colloidal gold or colored latex) or fluorescence detection, by commercial suppliers: ESEQuant™ LFT strip reader by Qiagen Lake Constance (Germany); an imaging system by Axxin Inc. (Australia); the handheld image capture LFT reader by Detekt Biomedical, LCC (USA); the cPOC™ reader from LRE Medical (Germany); the handheld DCN Fluorescent Test Visualizer (USA) [ ].

Techniques: Lysis, Nucleic Acid Purification, Amplification, Hybridization, Sequencing

Journal: Microelectronic Engineering

Article Title: Diagnostic tools for tackling febrile illness and enhancing patient management

doi: 10.1016/j.mee.2018.10.001

Figure Lengend Snippet: The EasyNAT™ cartridge from Ustar Biotechnologies (Hangzhou) Ltd. (handheld size). The integrated lateral flow test is visible. Image source: used from .

Article Snippet: Several technologies have been developed based on colorimetric (e.g. colloidal gold or colored latex) or fluorescence detection, by commercial suppliers: ESEQuant™ LFT strip reader by Qiagen Lake Constance (Germany); an imaging system by Axxin Inc. (Australia); the handheld image capture LFT reader by Detekt Biomedical, LCC (USA); the cPOC™ reader from LRE Medical (Germany); the handheld DCN Fluorescent Test Visualizer (USA) [ ].

Techniques: